Left-arm spinner Noman Ali was the main challenge for South Africa, leading to Pakistan’s gripping 93-run victory in the first Test in Lahore on Wednesday.
Chasing a formidable target of 277, the visitors, who are the reigning World Test champions, were dismissed for 183 on the fourth day.
Noman, awarded the man of the match title, took 4-79 and 10-191, achieving his third ten-wicket haul in Tests.
The hosts struggled in their second innings, managing 167 on a deteriorating pitch, but it was ultimately enough.
On Wednesday, with the tourists at 137-6 by lunchtime, the result seemed clear, and Sajid Khan soon dismissed Muthusamy for six after the break.
Fast bowler Shaheen Shah Afridi dismissed Kyle Verreynne (19), Prenelan Subrayen (eight), and Kagiso Rabada (zero), finishing with 4-33.
This victory marks an excellent start for Pakistan in the World Test Championship, following their last-place finish in the previous edition.
The second and final Test will commence in Rawalpindi from Monday.
Earlier in the day, Brevis aggressively challenged Pakistan’s spinners, reaching a career-best 54 runs with six fours and two sixes before Noman bowled him with a sharply turning delivery.
Just before lunch, Sajid broke opener Rickleton’s determined defense, dismissing him for a disciplined 45.
Pakistan’s first strike of the day came from fast bowler Shaheen, who trapped Tony de Zorzi for 16 without adding to the overnight score of 51-2.
Tristan Stubbs struggled to cope with the sharp turn and was on two when a premeditated reverse sweep off Noman safely landed in Salman Agha’s hands.
Brevis reached his second Test half-century with a six off Noman before becoming the spinner’s fourth victim.